Online Mendelian Inheritance in Man (OMIM) (2023)

  1. Aisenberg, A. C., Wilkes, B. M., Jacobson, J. O. The bcl-2 gene is rearranged in many diffuse B-cell lymphomas. Blood 71: 969-972, 1988. [PubMed: 2965608]

  2. Bakhshi, A., Jensen, J. P., Goldman, P., Wright, J. J., McBride, O. W., Epstein, A. L., Korsmeyer, S. J. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around J(H) on chromosome 14 and near a transcriptional unit on 18. Cell 41: 899-906, 1985. [PubMed: 3924412] [Full Text:]

  3. Bakhshi, A., Wright, J. J., Graninger, W., Seto, M., Owens, J., Cossman, J., Jensen, J. P., Goldman, P., Korsmeyer, S. J. Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc. Nat. Acad. Sci. 84: 2396-2400, 1987. [PubMed: 3104914] [Full Text:]

  4. Cang, S., Iragavarapu, C., Savooji, J., Song, Y., Liu, D. ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development. J. Hemat. Oncol. 8: 129, 2015. Note: Electronic Article. [PubMed: 26589495] [Full Text:]

  5. Chen, J., Flannery, J. G., LaVail, M. M., Steinberg, R. H., Xu, J., Simon, M. I. Bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc. Nat. Acad. Sci. 93: 7042-7047, 1996. [PubMed: 8692941] [Full Text:]

  6. Ciechomska, I. A., Goemans, G. C., Skepper, J. N., Tokovsky, A. M. Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function. Oncogene 28: 2128-2141, 2009. [PubMed: 19347031] [Full Text:]

  7. Cimmino, A., Calin, G. A., Fabbri, M., Iorio, M. V., Ferracin, M., Shimizu, M., Wojcik, S. E., Aqeilan, R. I., Zupo, S., Dono, M., Rassenti, L., Alder, H., Volinia, S., Liu, C., Kipps, T. J., Negrini, M., Croce, C. M. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Nat. Acad. Sci. 102: 13944-13949, 2005. Note: Erratum: Proc. Nat. Acad. Sci. 103: 2464-2465, 2006. [PubMed: 16166262] [Full Text:]

  8. Cleary, M. L., Sklar, J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc. Nat. Acad. Sci. 82: 7439-7443, 1985. [PubMed: 2865728] [Full Text:]

  9. Cleary, M. L., Smith, S. D., Sklar, J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47: 19-28, 1986. [PubMed: 2875799] [Full Text:]

  10. Croce, C. M. Personal Communication. Philadelphia, Pa. 1989.

  11. Das, R., Reddy, E. P., Chatterjee, D., Andrews, D. W. Identification of a novel Bcl-2 related gene, BRAG-1, in human glioma. Oncogene 12: 947-951, 1996. Note: Erratum: Oncogene 16: 429 only, 1998. [PubMed: 8649811]

  12. Del Gaizo Moore, V., Brown, J. R., Certo, M., Love, T. M., Novina, C. D., Letai, A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J. Clin. Invest. 117: 112-121, 2007. [PubMed: 17200714] [Full Text:]

  13. Deng, G., Podack, E. R. Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2. Proc. Nat. Acad. Sci. 90: 2189-2193, 1993. [PubMed: 8460122] [Full Text:]

  14. DiCroce, P. A., Krontiris, T. G. The BCL2 major breakpoint region is a sequence- and cell-cycle-specific binding site of the Ku antigen. Proc. Nat. Acad. Sci. 92: 10137-10141, 1995. [PubMed: 7479741] [Full Text:]

  15. Dominov, J. A., Kravetz, A. J., Ardelt, M., Kostek, C. A., Beermann, M. L., Miller, J. B. Muscle-specific BCL2 expression ameliorates muscle disease in laminin alpha-2-deficient, but not in dystrophin-deficient, mice. Hum. Molec. Genet. 14: 1029-1040, 2005. [PubMed: 15757977] [Full Text:]

  16. Farlie, P. G., Dringen, R., Rees, S. M., Kannourakis, G., Bernard, O. bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc. Nat. Acad. Sci. 92: 4397-4401, 1995. [PubMed: 7753817] [Full Text:]

  17. Fesus, L., Davies, P. J. A., Piacentini, M. Apoptosis: molecular mechanisms in programmed cell death. Europ. J. Cell Biol. 56: 170-177, 1991. [PubMed: 1802705]

  18. Fonseca-Pereira, D., Arroz-Madeira, S., Rodrigues-Campos, M., Barbosa, I. A. M., Domingues, R. G., Bento, T., Almeida, A. R. M., Ribeiro, H., Potocnik, A. J., Enomoto, H., Veiga-Fernandes, H. The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. Nature 514: 98-101, 2014. [PubMed: 25079320] [Full Text:]

  19. Frankel, S. R. Correction: location of bcl-2 oncogene. (Letter) New Eng. J. Med. 328: 141, 1993. [PubMed: 8416434] [Full Text:]

  20. Graninger, W. B., Seto, M., Boutain, B., Goldman, P., Korsmeyer, S. J. Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells. J. Clin. Invest. 80: 1512-1515, 1987. [PubMed: 3500184] [Full Text:]

  21. Haluska, F. G., Tsujimoto, Y., Croce, C. M. Mechanisms of chromosome translocation in B- and T-cell neoplasia. Trends Genet. 3: 11-15, 1987.

  22. He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., Korsmeyer, S., Packer, M., May, H. I., Hill, J. A., Virgin, H. W., Gilpin, C., Xiao, G., Bassel-Duby, R., Scherer, P. E., Levine, B. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 481: 511-515, 2012. Note: Erratum: Nature 503: 146 only, 2013. [PubMed: 22258505] [Full Text:]

  23. Hengartner, M. O., Horvitz, H. R. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76: 665-676, 1994. [PubMed: 7907274] [Full Text:]

  24. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D., Korsmeyer, S. J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336, 1990. [PubMed: 2250705] [Full Text:]

  25. Hoyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., Mathiasen, I. S., Jaattela, M. Control of macrophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Molec. Cell 25: 193-205, 2007. [PubMed: 17244528] [Full Text:]

  26. Jacobson, M. D., Burne, J. F., King, M. P., Miyashita, T., Reed, J. C., Raff, M. C. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361: 365-369, 1993. [PubMed: 8381212] [Full Text:]

  27. Ji, L., Mochon, E., Arcinas, M., Boxer, L. M. CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J. Biol. Chem. 271: 22687-22691, 1996. [PubMed: 8798441] [Full Text:]

  28. Korsmeyer, S. J. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80: 879-886, 1992. [PubMed: 1498330]

  29. Lang, G., Gombert, W. M., Gould, H. J. A transcriptional regulatory element in the coding sequence of the human Bcl-2 gene. Immunology 114: 25-36, 2005. [PubMed: 15606792] [Full Text:]

  30. Li, Q. J., Ashraf, M. F., Shen, D., Green, W. R., Stark, W. J., Chan, C.-C, O'Brien, T. P. The role of apoptosis in the pathogenesis of Fuchs endothelial dystrophy of the cornea. Arch. Ophthal. 119: 1597-1604, 2001. [PubMed: 11709009] [Full Text:]

  31. Limana, F., Urbanek, K., Chimenti, S., Quaini, F., Leri, A., Kajstura, J., Nadal-Ginard, B., Izumo, S., Anversa, P. bcl-2 overexpression promotes myocyte proliferation. Proc. Nat. Acad. Sci. 99: 6257-6262, 2002. [PubMed: 11983915] [Full Text:]

  32. Lin, B., Kolluri, S. K., Lin, F., Liu, W., Han, Y.-H., Cao, X., Dawson, M. I., Reed, J. C., Zhang, X. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 116: 527-540, 2004. [PubMed: 14980220] [Full Text:]

  33. Lossos, I. S., Czerwinski, D. K., Alizadeh, A. A., Wechser, M. A., Tibshirani, R., Botstein, D., Levy, R. Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. New Eng. J. Med. 350: 1828-1837, 2004. [PubMed: 15115829] [Full Text:]

  34. Marsden, V. S., O'Connor, L., O'Reilly, L. A., Silke, J., Metcalf, D., Ekert, P. G., Huang, D. C. S., Cecconi, F., Kuida, K., Tomaselli, K. J., Roy, S., Nicholson, D. W., Vaux, D. L., Bouillet, P., Adams, J. M., Strasser, A. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419: 634-637, 2002. [PubMed: 12374983] [Full Text:]

  35. Martinou, J.-C., Dubois-Dauphin, M., Staple, J. K., Rodriguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., Pietra, C., Huarte, J. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13: 1017-1030, 1994. [PubMed: 7946326] [Full Text:]

  36. McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., Korsmeyer, S. J. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57: 79-88, 1989. [PubMed: 2649247] [Full Text:]

  37. McGill, G. G., Horstmann, M., Widlund, H. R., Du, J., Motyckova, G., Nishimura, E. K., Lin, Y.-L., Ramaswamy, S., Avery, W., Ding, H.-F., Jordan, S. A., Jackson, I. J., Korsmeyer, S. J., Golub, T. R., Fisher, D. E. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109: 707-718, 2002. [PubMed: 12086670] [Full Text:]

  38. Migheli, A., Cavalla, P., Piva, R., Giordana, M. T., Schiffer, D. Bcl-2 protein expression in aged brain and neurodegenerative diseases. Neuroreport 5: 1906-1908, 1994. [PubMed: 7841373] [Full Text:]

  39. Mock, B. A., Givol, D., D'Hoostelaere, L. A., Huppi, K., Seldin, M. F., Gurfinkel, N., Unger, T., Potter, M., Mushinski, J. F. Mapping of the bcl-2 oncogene on mouse chromosome 1. Cytogenet. Cell Genet. 47: 11-15, 1988. [PubMed: 2895697] [Full Text:]

  40. Mufti, G. J., Hamblin, T. J., Oscier, D. G., Johnson, S. Common ALL with pre-B-cell features showing (8;14) and (14;18) chromosome translocations. Blood 62: 1142-1146, 1983. [PubMed: 6605167]

  41. Nakayama, K., Nakayama, K., Negishi, I., Kuida, K., Sawa, H., Loh, D. Y. Targeted disruption of Bcl-2-alpha-beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Nat. Acad. Sci. 91: 3700-3704, 1994. [PubMed: 8170972] [Full Text:]

  42. Negrini, M., Silini, E., Kozak, C., Tsujimoto, Y., Croce, C. M. Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 49: 455-463, 1987. [PubMed: 3032455] [Full Text:]

  43. Ngan, B.-Y., Chen-Levy, Z., Weiss, L. M., Warnke, R. A., Cleary, M. L. Expression in non-Hodgkin's lymphoma of the BCL-2 protein associated with the t(14;18) chromosomal translocation. New Eng. J. Med. 318: 1638-1644, 1988. [PubMed: 3287162] [Full Text:]

  44. Nishimura, E. K., Granter, S. R., Fisher, D. E. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307: 720-724, 2005. [PubMed: 15618488] [Full Text:]

  45. Nunez, G., Hockenbery, D., McDonnell, T. J., Sorensen, C. M., Korsmeyer, S. J. Bcl-2 maintains B cell memory. Nature 353: 71-73, 1991. [PubMed: 1908951] [Full Text:]

  46. Nunez, G., Seto, M., Seremetis, S., Ferrero, D., Grignani, F., Korsmeyer, S. J., Dalla-Favera, R. Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells. Proc. Nat. Acad. Sci. 86: 4589-4593, 1989. [PubMed: 2543982] [Full Text:]

  47. O'Brien, S. J., Bonner, T. I., Cohen, M., O'Connell, C., Nash, W. G. Mapping of an endogenous retroviral sequence to human chromosome 18. Nature 303: 74-77, 1983. [PubMed: 6843662] [Full Text:]

  48. Pedrini, S., Sau, D., Guareschi, S., Bogush, M., Brown, R. H., Jr., Naniche, N., Kia, A., Trotti, D., Pasinelli, P. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. Hum. Molec. Genet. 19: 2974-2986, 2010. [PubMed: 20460269] [Full Text:]

  49. Pegoraro, L., Palumbo, A., Erikson, J., Falda, M., Giovanazzo, B., Emanuel, B. S., Rovera, G., Nowell, P. C., Croce, C. M. A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia. Proc. Nat. Acad. Sci. 81: 7166-7170, 1984. [PubMed: 6334305] [Full Text:]

  50. Qin, B., Xiao, B., Liang, D., Xia, J., Li, Y., Yang, H. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression. Biochem. Biophys. Res. Commun. 410: 127-133, 2011. [PubMed: 21640710] [Full Text:]

  51. Raghavan, S. C., Swanson, P. C., Wu, X., Hsieh, C.-L., Lieber, M. R. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature 428: 88-93, 2004. [PubMed: 14999286] [Full Text:]

  52. Reed, J. C., Cuddy, M., Slabiak, T., Croce, C. M., Nowell, P. C. Oncogenic potential of bcl-2 demonstrated by gene transfer. Nature 336: 259-261, 1988. [PubMed: 2848196] [Full Text:]

  53. Roberts, A. W., Davids, M. S., Pagel, J. M., Kahl, B. S., Puvvada, S. D., Gerecitano, J. F., Kipps, T. J., Anderson, M. A., Brown, J. R., Gressick, L., Wong, S., Dunbar, M., Zhu, M., Desai, M. B., Cerri, E., Enschede S. H., Humerickhouse, R. A., Wierda, W. G., Seymour, J. F. Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. New Eng. J. Med. 374: 311-322, 2016. [PubMed: 26639348] [Full Text:]

  54. Sagot, Y., Dubois-Dauphin, M., Tan, S. A., de Bilbao, F., Aebischer, P., Martinou, J.-C., Kato, A. C. Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J. Neurosci. 15: 7727-7733, 1995. [PubMed: 7472523] [Full Text:]

  55. Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., Korsmeyer, S. J. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888, 1991. [PubMed: 1835668] [Full Text:]

  56. Silverman, G. A., Green, E. D., Young, R. L., Jockel, J. I., Domer, P. H., Korsmeyer, S. J. Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene. Proc. Nat. Acad. Sci. 87: 9913-9917, 1990. [PubMed: 2263642] [Full Text:]

  57. Strasser, A., Harris, A. W., Cory, S. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67: 889-899, 1991. [PubMed: 1959134] [Full Text:]

  58. Sugino, N., Suzuki, T., Kashida, S., Karube, A., Takiguchi, S., Kato, H. Expression of Bcl-2 and Bax in the human corpus luteum during the menstrual cycle in early pregnancy: regulation by human chorionic gonadotropin. J. Clin. Endocr. Metab. 85: 4379-4386, 2000. [PubMed: 11095483] [Full Text:]

  59. Tsujimoto, Y., Bashir, M. M., Givol, I., Cossman, J., Jaffe, E., Croce, C. M. DNA rearrangements in human follicular lymphoma can involve the 5-prime or the 3-prime region of the bcl-2 gene. Proc. Nat. Acad. Sci. 84: 1329-1331, 1987. [PubMed: 3547408] [Full Text:]

  60. Tsujimoto, Y., Cossman, J., Jaffe, E., Croce, C. M. Involvement of the bcl-2 gene in human follicular lymphoma. Science 228: 1440-1443, 1985. [PubMed: 3874430] [Full Text:]

  61. Tsujimoto, Y., Croce, C. M. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Nat. Acad. Sci. 83: 5214-5218, 1986. [PubMed: 3523487] [Full Text:]

  62. Tsujimoto, Y., Finger, L. R., Yunis, J., Nowell, P. C., Croce, C. M. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226: 1097-1099, 1984. [PubMed: 6093263] [Full Text:]

  63. Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E., Croce, C. M. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229: 1390-1393, 1985. [PubMed: 3929382] [Full Text:]

  64. Tsujimoto, Y. Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells. Proc. Nat. Acad. Sci. 86: 1958-1962, 1989. [PubMed: 2538824] [Full Text:]

  65. Vanasse, G. J., Halbrook, J., Thomas, S., Burgess, A., Hoekstra, M. F., Disteche, C. M., Willerford, D. M. Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase. J. Clin. Invest. 103: 1669-1675, 1999. [PubMed: 10377173] [Full Text:]

  66. Vaskivuo, T. E., Anttonen, M., Herva, R., Billig, H., Dorland, M., Te Velde, E. R., Stenback, F., Heikinheimo, M., Tapanainen, J. S. Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis-related proteins, and transcription factor GATA-4. J. Clin. Endocr. Metab. 86: 3421-3429, 2001. [PubMed: 11443219] [Full Text:]

  67. Vaux, D. L., Cory, S., Adams, J. M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442, 1988. [PubMed: 3262202] [Full Text:]

  68. Wang, H.-G., Rapp, U. R., Reed, J. C. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87: 629-638, 1996. [PubMed: 8929532] [Full Text:]

  69. Williams, G. T. Programmed cell death: apoptosis and oncogenesis. Cell 65: 1097-1098, 1991. [PubMed: 1648446] [Full Text:]

  70. Yunis, J. J., Frizzera, G., Oken, M. M., McKenna, J., Theologides, A., Arnesen, M. Multiple recurrent genomic defects in follicular lymphoma: a possible model for cancer. New Eng. J. Med. 316: 79-84, 1987. [PubMed: 3537802] [Full Text:]

  71. Yunis, J. J., Mayer, M. G., Arnesen, M. A., Aeppli, D. P., Oken, M. M., Frizzera, G. Bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma. New Eng. J. Med. 320: 1047-1054, 1989. [PubMed: 2648153] [Full Text:]

  72. Yunis, J. J., Oken, M. M., Kaplan, M. E., Ensrud, K. M., Howe, R. R., Theologides, A. Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma. New Eng. J. Med. 307: 1231-1236, 1982. [PubMed: 7133054] [Full Text:]

Top Articles
Latest Posts
Article information

Author: Domingo Moore

Last Updated: 20/02/2023

Views: 5935

Rating: 4.2 / 5 (53 voted)

Reviews: 92% of readers found this page helpful

Author information

Name: Domingo Moore

Birthday: 1997-05-20

Address: 6485 Kohler Route, Antonioton, VT 77375-0299

Phone: +3213869077934

Job: Sales Analyst

Hobby: Kayaking, Roller skating, Cabaret, Rugby, Homebrewing, Creative writing, amateur radio

Introduction: My name is Domingo Moore, I am a attractive, gorgeous, funny, jolly, spotless, nice, fantastic person who loves writing and wants to share my knowledge and understanding with you.